Django is one of the leading Python frameworks used to create full-stack web applications. In this comprehensive guide, you will explore the intricacies of testing and debugging within the Django framework, focusing on advanced methodologies and essential tools. Beginning with the fundamentals of Django unit and integration testing, you will delve into advanced techniques such as mocking, testing middleware, and profiling for optimal performance.

Django is a “batteries-included” framework. It has a wide array of built-in features that handle common web development tasks: URL routing, template engine, object-relational mapping (ORM), and database schema migrations. This makes it highly efficient for rapid development, allowing developers to focus on building their applications' unique aspects without reinventing basic functionalities.